What is the best treatment for refractory restless legs syndrome (RLS)?
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What is the best treatment for refractory restless legs syndrome (RLS)? Evidence-Based Answer: Monotherapy with gabapentin or pregabalin improves RLS symptoms (SOR: B, small RCTs) as does therapy with high-potency opioids (SOR: C, case series). So, for RLS symptoms that do not respond to a dopaminergic agonist, current guidelines recommend changing to a different dopamine agonist, changing to or adding an anticonvulsant, or changing to a high-potency opioid (SOR: C, expert opinion).
Evidence Based Practice 17(9): E13