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    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2006 Dissertations (MU)
    • 2006 MU dissertations - Freely available online
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    Sensory integration during blood loss in conscious rabbits

    Shafford, Heidi L.
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    [PDF] research.pdf (2.129Mb)
    Date
    2006
    Format
    Thesis
    Metadata
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    Abstract
    Central nervous system integration of sensory inputs is critical for orchestrating physiological responses to stress. The focus of my doctoral research was investigating the physiological consequences of sensory stimulation to begin to answer the question of how the body integrates information about stress, pain and other sensory inputs. Conscious, chronically instrumented rabbits were used to minimize the influence of anesthesia and surgery. Two studies explored the role of the midbrain periaqueductal gray in modulating the cardiovascular response to hemorrhage and sensory stimulation. Other studies describe the assessment and use of a model of visceral pain, colorectal distension, to quantify the effect of concurrent stress and pain on the cardiovascular and respiratory response to blood loss. The results from these studies provide insight into 1) a central nervous system site for integration of multiple sensory inputs; and 2) potential sex differences in the response to concurrent stress, pain and hemorrhage.
    URI
    https://doi.org/10.32469/10355/4395
    https://hdl.handle.net/10355/4395
    Degree
    Ph. D.
    Thesis Department
    Veterinary biomedical sciences (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Copyright held by author.
    Collections
    • 2006 MU dissertations - Freely available online
    • Biomedical Sciences electronic theses and dissertations (MU)

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