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    • Theses (MU)
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    • 2013 MU theses - Freely available online
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    Bisphenol A (BPA) in human serum and urine : exposure via dermal absorption from thermal paper receipts and oral ingestion after transfer from hand to food

    Hormann, Annette M.
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    Date
    2013
    Format
    Thesis
    Metadata
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    Abstract
    Bisphenol A (BPA) exposure is thought to be mainly due to absorption from the gut by oral ingestion. However thermal receipt paper represents another potential source of BPA exposure via direct absorption through the skin or indirectly via transfer of the chemical to food. This study examined the relative abundance of BPA in thermal receipt papers from businesses in Columbia. Our aim was to determine whether handling thermal receipt paper prior to eating food has an effect on serum and urine BPA concentrations. Measurements of BPA in 51 receipts were taken to assess the amount of the BPA available for dermal transfer. Blood and serum measurements from volunteer human participants were taken: Controls (n=10) with no manipulation, participants exposed to BPA in thermal paper either dermally (n=24) or dermally and orally (n=10) after a twoday period of avoiding exposure to BPA. BPA was found to be present in 46% of the receipts measured (mean ±SEM: 19.7±1.0). The amount of BPA transferred to hands was about 100-fold higher when wet with hand sanitizer than dry. BPA transferred to wet hands and then consequently to French fries that were eaten. This resulted in significant elevation of unconjugated serum BPA from a baseline of 0.28.5±1.2 to a maximum of 5.9±2.6 ng/ml after 60 min. With total urine BPA (æg/g creatinine) 0.5±0.2 at baseline and 23.4±7.4 at 90 minutes after being exposed from a receipt that contained 27.2 mg BPA/g receipt paper. Serum concentrations were suggestive of both oral and dermal BPA transmission. In conclusion, thermal paper is a significant source of BPA exposure that regulatory agencies have not included in exposure estimates.
    URI
    https://hdl.handle.net/10355/43992
    https://doi.org/10.32469/10355/43992
    Degree
    M.A.
    Thesis Department
    Biological sciences (MU)
    Collections
    • 2013 MU theses - Freely available online
    • Biological Sciences electronic theses and disserations (MU)

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