dc.contributor.advisor | Forgács, Gabor, 1949- | eng |
dc.contributor.author | Jakab, Karoly Robert, 1974- | eng |
dc.date.issued | 2006 | eng |
dc.date.submitted | 2006 Spring | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Title from title screen of research.pdf file (viewed on March 25, 2009) | eng |
dc.description | Vita. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | Thesis (Ph.D.) University of Missouri-Columbia 2006. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- Physics. | eng |
dc.description.abstract | This research presents a study of biological self-assembly in which we create 3D living functional tissue structures by exploiting the self organizing capacity of cells and tissues. Tissues composed of adhesive and motile cells mimic the behavior of viscoelastic liquids on both global and local scales. We exploited the concept of tissue liquidity to engineer tissue structures of relevant geometries encountered in the living organism. Embedding model tissue fragments in the form of spherical cell aggregates into biocompatible hydrogels, we demonstrated that by optimizing the cell-cell and cell-gel interactions, upon fusion long lived tissue structures emerge. We developed a rapid prototyping technique, "bioprinting", and automated devices capable to produce standardized "bioink" particles in the form of cell aggregates. The tissues created with our bioprinter fused into biologically relevant geometries and showed functional characteristics. Our efforts represent an important step toward building complex organ modules via biological self-assembly. | eng |
dc.identifier.merlin | b66676563 | eng |
dc.identifier.oclc | 317070175 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/4426 | |
dc.identifier.uri | https://doi.org/10.32469/10355/4426 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.subject.lcsh | Cytoskeleton | eng |
dc.subject.lcsh | Cadherins | eng |
dc.subject.lcsh | Tissue engineering | eng |
dc.title | Physical mechanisms of cell rearrangements: from tissue liquidity to artificial organ structures | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Physics and astronomy (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |