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dc.contributor.advisorForgács, Gabor, 1949-eng
dc.contributor.authorJakab, Karoly Robert, 1974-eng
dc.date.issued2006eng
dc.date.submitted2006 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on March 25, 2009)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph.D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physics.eng
dc.description.abstractThis research presents a study of biological self-assembly in which we create 3D living functional tissue structures by exploiting the self organizing capacity of cells and tissues. Tissues composed of adhesive and motile cells mimic the behavior of viscoelastic liquids on both global and local scales. We exploited the concept of tissue liquidity to engineer tissue structures of relevant geometries encountered in the living organism. Embedding model tissue fragments in the form of spherical cell aggregates into biocompatible hydrogels, we demonstrated that by optimizing the cell-cell and cell-gel interactions, upon fusion long lived tissue structures emerge. We developed a rapid prototyping technique, "bioprinting", and automated devices capable to produce standardized "bioink" particles in the form of cell aggregates. The tissues created with our bioprinter fused into biologically relevant geometries and showed functional characteristics. Our efforts represent an important step toward building complex organ modules via biological self-assembly.eng
dc.identifier.merlinb66676563eng
dc.identifier.oclc317070175eng
dc.identifier.urihttps://hdl.handle.net/10355/4426
dc.identifier.urihttps://doi.org/10.32469/10355/4426eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshCytoskeletoneng
dc.subject.lcshCadherinseng
dc.subject.lcshTissue engineeringeng
dc.titlePhysical mechanisms of cell rearrangements: from tissue liquidity to artificial organ structureseng
dc.typeThesiseng
thesis.degree.disciplinePhysics and astronomy (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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