Does any antidepressant besides bupropion help smokers quit?

Abstract

Q: Does any antidepressant besides bupropion help smokers quite? Evidence-based answer: Yes, nortriptyline approximately doubles smoking cessation rates, an effect comparable to bupropion. Adding nortriptyline to nicotine replacement therapy (NRT) doesn't improve rates further (strength of recommendation [SOR]: A, systematic review of randomized controlled trials [RCTs]). Selective serotonin reuptake inhibitors (SSRIs; fluoxetine, paroxetine, sertraline, citalopram), venlafaxine, mono-amine oxidase inhibitors (MAOIs; moclobemide, selegiline), doxepin, and St. John's wort don't improve smoking cessation rates (SOR: A, systematic reviews and RCTs).