Does any antidepressant besides bupropion help smokers quit?
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Q: Does any antidepressant besides bupropion help smokers quite? Evidence-based answer: Yes, nortriptyline approximately doubles smoking cessation rates, an effect comparable to bupropion. Adding nortriptyline to nicotine replacement therapy (NRT) doesn’t improve rates further (strength of recommendation [SOR]: A, systematic review of randomized controlled trials [RCTs]). Selective serotonin reuptake inhibitors (SSRIs; fluoxetine, paroxetine, sertraline, citalopram), venlafaxine, mono-amine oxidase inhibitors (MAOIs; moclobemide, selegiline), doxepin, and St. John’s wort don’t improve smoking cessation rates (SOR: A, systematic reviews and RCTs).
Journal of Family Practice, 63(11) 2014: 680-681, 688.