Is modafinil safe and effective at improving mental performance in shift workers?
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Is modafinil safe and effective at improving mental performance in shift workers? Bottom line: Modafinil decreases attention lapses and minimally improves subjective mental state in shift workers (SOR: B, 2 limited RCTs). However, drug monitoring agencies have issued warnings about its safety based on associations with serious cutaneous, psychiatric, and cardiovascular events leading to more restrictive indications (SOR: C, expert opinion).
Evidence Based Practice 17(12): 14