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dc.contributor.advisorChandrasekhar, Anand, 1965-eng
dc.contributor.authorVanderlaan, Gary, 1978-eng
dc.date.issued2006eng
dc.date.submitted2006 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on April 29, 2009)eng
dc.descriptionVita.eng
dc.descriptionThesis (Ph.D.) University of Missouri-Columbia 2006.eng
dc.description.abstractInduction of neurons in the correct number and location is essential for the proper development and function of a nervous system. Signaling mediated by the Hedgehog (Hh) family of secreted proteins plays a vital role in the induction of the vertebrate branchiomotor neurons, which are located in the brainstem and regulate chewing, swallowing, and sound production. The Gli family of zinc-finger transcription factors mediates Hh signaling in all vertebrates. For instance, zebrafish gli1 is required for motor neuron specification in the brainstem but not in the spinal cord, whereas mouse gli genes function redundantly for motor neuron development. We examined motor neuron induction in you-too (yot) mutants, which encode dominant repressor forms of Gli2 (Gli2DR), and following morpholino-mediated knockdown of gli3 function. Motor neuron induction at all axial levels was reduced in yot (gli2DR) mutant embryos, and gli1 or gli3 knockdown in yot (gli2DR) mutants resulted in severe or complete loss of motor neurons. These observations demonstrate that Gli activator function (encoded by gli1, gli2, and gli3) is essential for motor neuron induction and Hh-regulated gene expression in zebrafish.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.identifier.merlinb67203243eng
dc.identifier.oclc319639577eng
dc.identifier.urihttps://doi.org/10.32469/10355/4461eng
dc.identifier.urihttps://hdl.handle.net/10355/4461
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subject.lcshEfferent pathwayseng
dc.subject.lcshNervous systemeng
dc.subject.lcshMotor neuronseng
dc.titleDifferential roles for hedgehog signaling in motor neuron developmenteng
dc.typeThesiseng
thesis.degree.disciplineBiological sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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