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dc.contributor.advisorKeisler, Duane H.eng
dc.contributor.authorBerg, Erika L., 1972-eng
dc.date.issued2006eng
dc.date.submitted2006 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on July 31, 2007)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.eng
dc.description.abstractObesity in horses is associated with a number of maladies including insulin resistance and laminitis; therefore studies investigating the metabolic physiology of equine were done. In our first study, we characterized the profiles of leptin, insulin-like growth factor-1, and thyroid stimulating hormone in mares and foals in the peri-parturient period. The highest concentration of all hormones was found in the first milk sample, which is in agreement with other equine research. This study also provided the first data on leptin concentrations in the neonatal foal. In our second study, we examined the link between leptin and adrenocorticoid hormones by administering the mineralocorticoid receptor antagonist spironolactone to pony mares. We found no change in cortisol or leptin concentrations between treatments, but did see a trend for increased aldosterone concentrations in the blood of spironolactone treated ponies over time. Further work is necessary to elucidate the relationship between leptin and adrenocorticoids in equine. In our third study, we investigated the effects lipoic acid supplementation on blood glucose and insulin responses, as well as leptin concentrations in pony mares. We found no differences between treatments for blood glucose or leptin concentrations during a glucose tolerance test; however there was a trend for decreased insulin concentrations. These results suggest that lipoic acid may improve insulin effectiveness and warrant further investigation into the potential benefits of lipoic acid supplementation in the management of insulin resistance in equine.eng
dc.identifier.merlinb59264470eng
dc.identifier.oclc160116016eng
dc.identifier.urihttps://hdl.handle.net/10355/4472
dc.identifier.urihttps://doi.org/10.32469/10355/4472eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshObesity in animalseng
dc.subject.lcshHorses -- Diseaseseng
dc.subject.lcshLaminitiseng
dc.subject.lcshHorses -- Physiologyeng
dc.subject.lcshInsulin resistanceeng
dc.titleEndocrinology of equine metabolic pathophysiologyeng
dc.typeThesiseng
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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