Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2013 Theses (MU)
    • 2013 MU theses - Access restricted to UM
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2013 Theses (MU)
    • 2013 MU theses - Access restricted to UM
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    The use of a lysostaphin fusion protein as a dry-cow treatment for chronic Staphylococcus aureua mastitis in dairy cattle

    Hoernig, Kenton J. (Kenton John)
    View/Open
    [PDF] research.pdf (798.3Kb)
    [PDF] public.pdf (52.25Kb)
    [PDF] short.pdf (10.11Kb)
    Date
    2013
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This study evaluated the efficacy of a lysostaphin-fusion protein (Lyso-PTD) as a dry-cow therapy for the treatment of experimentally-induced chronic, subclinical Staphylococcus aureus mastitis. Twenty-two Holstein dairy cows were experimentally infected with Staph aureus in a single pair of diagonal mammary quarters approximately 45 d before dry-off. Staphylococcus aureus infected mammary quarters of cows were randomly assigned to one of two groups at dry-off 1) 279 mg of Lyso-PTD in 50 mL of vehicle (n = 11 cows; 22 quarters) or 2) 50 mL of vehicle solution (n =11 cows; 22 quarters) by intramammary infusions. All cows were followed for 30 d post-partum to determine cure rates using bacteriologic culture, somatic cell counts, and clinical mastitis scores. No cures were recorded in either the treatment or control groups. Milk somatic cell count, bacterial colony counts, and mastitis scores did not significantly differ between groups (P = 0.832, P = 0.117, and P= 0.108, respectively). Follow-up studies in lactating cows revealed neither increasing the Lyso-PTD dose to 1340mg nor treatment with cephapirin sodium showed improved efficacy. In conclusion, Lyso-PTD was not an effective dry-cow therapeutic for chronic, subclinical Staph. aureus mastitis at the experimental dose and formulation used.
    URI
    https://hdl.handle.net/10355/44735
    https://doi.org/10.32469/10355/44735
    Degree
    M.S.
    Thesis Department
    Veterinary biomedical sciences (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2013 MU theses - Access restricted to UM
    • Biomedical Sciences electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems