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dc.contributor.advisorRogers, Elizabeth E.eng
dc.contributor.authorMaurer, Alberto, 1970-eng
dc.date.issued2006eng
dc.date.submitted2006 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on July 18, 2008)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Genetics area program.eng
dc.description.abstractIron is an essential element for plant survival. However, in excess, it is deleterious to the organism. In the present thesis we describe a functional genomic approach and a mutant screen directed towards increasing our understanding of iron homeostasis in the Strategy I model plant Arabidopsis thaliana. For the functional genomic approach, Affymetrix ATH-1 microarrays were hybridized with RNA extracted from iron-deficient and sufficient Arabidopsis plants. The resulting datasets were analyzed, and ten genes were chosen for further studies. Eight of them did not appear to be related to iron regulation. The other two belong to a small sub-family of four genes. All four were up-regulated in shoots and roots of iron-deficient plants. We hypothesize that all four provide redundancy to each other. Finally, we show the screening of mutant plants with potential disruptions in iron-homeostasis system. One mutation was mapped to locus At2g34740 which encodes AtATase2 (EC 2.4.2.14). The mutation disrupted the chloroplastic purine biosynthesis pathway, which resulted in damaged chloroplasts, affecting metal homeostasis throughout the plant.eng
dc.identifier.merlinb64154774eng
dc.identifier.oclc234238073eng
dc.identifier.urihttp://hdl.handle.net/10355/4476eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshPlantseng
dc.subject.lcshArabidopsis thaliana -- Effect of ferrous sulfate oneng
dc.subject.lcshHomeostasiseng
dc.titleMolecular and genetic studies of iron homeostasis in Arabidopsiseng
dc.typeThesiseng
thesis.degree.disciplineGenetic Area Program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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