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dc.contributor.advisorDabbagh, Ousamaeng
dc.contributor.authorBosanquet, James Percivaleng
dc.date.issued2010eng
dc.date.submitted2010eng
dc.description"December 2010."eng
dc.description"A Thesis presented to the Faculty of the Graduate School at the University of Missouri In Partial Fulfillment of the Requirements for the Degree Master of Science."eng
dc.descriptionThesis supervisor: Ousama Dabbagh, MD MSPH FCCP.eng
dc.description.abstractStudy Objectives: Obstructive sleep apnea (OSA) has been linked to a large number of cardiovascular diseases. However, the link between OSA and venous thromboembolic events (VTE) remains unclear. We sought to study the possible association between VTE and OSA. Design: Retrospective study (August 1999 - April 2009). Setting: University Tertiary Center. Patients: We retrospectively collected data on patients with objectively confirmed VTE. Primary outcome was prevalence of OSA defined as an apnea-hypopnea index (AHI) > 5. Data on demographics and comorbidities were recorded as well as body-mass index was calculated. Measurements and Results: 840 patients were identified as having VTE and analyzed for presence/absence of co-morbidities. Of 840 patients, 130 (15.5%) were also diagnosed with OSA. Compared to the control group (no OSA), those who had OSA were more obese (83.8% versus 43.8%) and had statistically higher prevalence of diabetes, coronary artery disease (CAD), and congestive heart failure (CHF). OSA patients had higher prevalence of pulmonary embolism but similar prevalence of deep vein thrombosis. Conclusions: In this VTE cohort, the prevalence of OSA (15.5%) appears to be higher than that of the general population (2-10%). Our data suggest that patients with both OSA and VTE are more likely to be obese with diagnoses of CAD, CHF, and diabetes than their counterparts with VTE alone. OSA patients had higher prevalence of pulmonary embolism compared to controls. Although OSA has been clearly linked to arterial thrombosis, this study also suggests a link between OSA and venous thrombotic disorders.eng
dc.description.bibrefIncludes bibliographical references (pages 32-37).eng
dc.format.extent1 online resource (vi, 50 pages) : illustrationseng
dc.identifier.oclc900553485eng
dc.identifier.urihttps://hdl.handle.net/10355/44845
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.subjectPathologyeng
dc.titlePatients with venous thromboembolism have higher prevalence of obstructive sleep apnea than the general populationeng
dc.typeThesiseng
thesis.degree.disciplinePathology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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