What is the most effective therapy for childhood attention deficit hyperactivity disorder (ADHD)?
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What is the most effective therapy for childhood attention deficit hyperactivity disorder (ADHD)? Bottom line: Osmotically released methylphenidate is slightly more effective than atomoxetine for treating the symptoms of ADHD, whereas immediate-release methylphenidate shows no benefit over atomoxetine (SOR: B, metaanalysis of RCTs with significant heterogeneity). Atomoxetine is more effective than placebo. The addition of clonidine extended-release (XR) in patients who had an inadequate response to stimulant medication monotherapy is also beneficial (SOR: B, RCTs).
Evidence Based Practice 18(2): 14