What is the best beta-blocker for systolic heart failure?
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Q: What is the best beta-blocker for systolic heart failure? Evidence-based answer: Three beta-blockers—carvedilol, metoprolol succinate, and bisoprolol—reduce mortality equally (by about 30% over one year) in patients with Class III or IV systolic heart failure. Insufficient evidence exists comparing equipotent doses of these medications head-to-head to recommend any one over the others (strength of recommendation [SOR]: A, systematic review/meta-analysis).
Journal of Family Practice, 64(2) 2015: 122-123.