BID vs TID dosing of unfractionated heparin for venous thromboembolism (VTE) prophylaxis in hospitalized patients
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A 2011 meta-analysis of 16 RCTs involved nearly 28,000 hospitalized nonsurgical, nonstroke patients with conditions including heart failure, respiratory disease, and infection.1 It examined the effectiveness of BID versus TID dosing of 5,000 units of subcutaneous unfractionated heparin (UFH) for deep vein thrombosis (DVT) prophylaxis. The authors used a mixed-treatment analysis, which included indirect comparisons from RCTs that had 1 randomization arm in common (allowing comparisons of UFH doses from trials that used UFH and other comparators).
Evidence-based practice 18, no. 03 (2015): 6