Can metformin be used safely in a patient with elevated creatinine concentration?
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Can metformin be used safely in a patient with elevated creatinine concentration? Bottom line: Metformin is likely safe in patients with mild chronic kidney disease with reduced dosing and close monitoring (SOR: B, systematic review of cohort studies). However, caution should be advised in patients with multiple risk factors for lactic acidosis.
Evidence Based Practice 18(3): 14