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dc.contributor.advisorGiuliano, Elizabetheng
dc.contributor.authorDonnelly, Kevin S.eng
dc.date.issued2014eng
dc.date.submitted2014 Falleng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corneal disease is a common cause of blindness in horses as a result of various causes including traumatic, autoimmune, neoplastic, or infectious disease. Although successful treatment of these underlying diseases may salvage the globe, the resulting corneal fibrosis from these pathologic processes can lead to significant vision loss. The objective of this research was to evaluate several potential therapies, nanoparticle gene therapy and a histone deacetylase inhibitor, for inhibiting the differentiation of equine corneal fibroblasts into myofibroblasts in vitro. This differentiaion of fibroblast to myofibroblast has been determined to be the major event responsible for corneal fibrosis, and is initiated by the presence of transforming growth factor beta. Our results indicate that polyethylenimine nanoparticle therapy is safe and effective and when delivering decorin, a natural antagonist of transforming growth factor beta, fibrosis is significantly inhibited in vitro. Additionally the histone deacytelase inhibitor suberoylanilide hydroxamic acid is an effective inhibitor of equine corneal fibrosis in vitro.eng
dc.identifier.urihttps://hdl.handle.net/10355/45719
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.source.originalSubmitted by University of Missouri--Columbia Graduate School.eng
dc.titleTargeting the myofibroblast : new strategies in managing equine corneal fibrosiseng
dc.typeThesiseng
thesis.degree.disciplineBiomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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