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    Videofluoroscopic characterization of swallowing impairment in mouse models of amyotrophic lateral sclerosis and advanced aging

    Brooks, Ryan Thomas
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    Date
    2014
    Format
    Thesis
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study was to establish a videofluoroscopic swallow study (VFSS) protocol for mice that permits identification of translational biomarkers of swallowing impairment in mouse models of human conditions. Animals tested included the SOD1-G93A mouse model of ALS and aged C57 mice, which we propose as a model of presbyphagia (age related swallowing impairment). A protocol was established using 49 mice divided into three groups: 16 aged C57 mice (18-24 months of age), 21 healthy young mice (4-8 months of age), and 12 SOD1-G93A end-stage mice. Videos were analyzed to quantify four swallow parameters: lick rate equivalent, number of licks (lick rate equivalent) per swallow, swallow rate, and interswallow interval. Results showed that aged C57 mice and SOD1-G93A mice licked significantly slower than healthy young controls. Aged C57 mice swallowed slower than both healthy young mice and SOD1 endstage mice. This study provides novel evidence that elderly C57 mice swallow and lick more slowly than healthy young mice, which validates this strain as a naturally occurring model of presbyphagia. Future research will identify additional swallow parameters that will permit better detection and characterization of dysphagia in mouse models of ALS and presbyphagia.
    URI
    https://hdl.handle.net/10355/45837
    Degree
    M.H.S.
    Thesis Department
    Communication science and disorders (MU)
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    Access is limited to the campuses of the University of Missouri.
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    • 2014 MU theses - Access restricted to UM
    • Communication Science and Disorders electronic theses and dissertations (MU)

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