dc.contributor.advisor | Gahl, John M. (John Michel) | eng |
dc.contributor.advisor | Culter, Cathy | eng |
dc.contributor.author | Li, Mingda | eng |
dc.date.issued | 2014 | eng |
dc.date.submitted | 2014 Spring | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted therapy of cancer, by binding the radionuclide with a carrier agent, provides more accurate delivery to focal tumor cell with low uptake in normal organs. In this paper, a new radio-loaded nanoparticle has been explored. A method for loading [superscript 177]Lu into MCM-41 was evaluated by varying starting material and loading reaction factors. For the procedure of [superscript 177]Lu loaded MCM-41, cetyltrimethylammonium bromide was dissolved in a solution of 384 ml of MilliQ water heated at 45[degree sign]C and then 2 M NaOH aqueous solution was added. The mixture was stirred vigorously at 80[degree sign]C for 0.5 h. Then tetraethylorthosilicate was added dropwise with vigorous stirring for another 2 h, followed by filtration and drying in the oven at 100 [degree sign]C for 12 h. Grounded powder was calcined in furnace at 550 ?C for 5 hours to remove the surfactant. And then MCM-41 solution was prepared by its fine powder in MilliQ water to give a concentration of 50 mg/ml. The reaction mixture consisted of a 150 [micro]l aliquot of the stock solution containing 20 [micro]g MCM-41(0.2669 mmol) and 150 [micro]l of [superscript 177]LuCl[subscript 3] solution (76.5 MBq) to which was then added 500 [micro]l of 0.01 M LaCl3 ?5 ?mol) mixed at room temperature and then 1 M NaOH was added to reach pH =6.5 for 1 hour. This novel synthesis method shows an over 99 % loading percentage of [superscript 177]Lu-MCM-41. | eng |
dc.identifier.uri | https://hdl.handle.net/10355/45840 | |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campuses of the University of Missouri. | eng |
dc.title | Fabrication of a novel radiopharmaceutical: lutetium-177 loaded MCM-41mesoporous silica | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Chemical engineering (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Masters | eng |
thesis.degree.name | M.S. | eng |