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    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2006 Theses (MU)
    • 2006 MU theses - Freely available online
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    Photoacoustic detection of metastatic melanoma in the human circulatory system

    Weight, Ryan Michael, 1983-
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    [PDF] research.pdf (35.22Mb)
    Date
    2006
    Format
    Thesis
    Metadata
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    Abstract
    Detection of disseminating tumor cells can function as an early warning system, alerting the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease while late stage detection can serve as an indicator of the effectiveness of chemotherapeutics. We propose a system for the detection of metastatic circulating tumor cells based upon the thermo-elastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection system capable of determining the presence of disseminating cells within the circulatory system in vitro. Detection trials consisting of a human melanoma cell line resulted in a detection threshold on the order of 10 individual cells. Melanoma cells were introduced into human blood in vitro to mimic a metastatic envrionment. Results imply the potential to assay simple blood draws from healthy and metastatic patients for the presence of cancerous melanoma providing an unprecedented method for routine cancer screening.
    URI
    https://hdl.handle.net/10355/4589
    https://doi.org/10.32469/10355/4589
    Degree
    M.S.
    Thesis Department
    Biological engineering (MU)
    Collections
    • 2006 MU theses - Freely available online
    • Biological Engineering electronic theses and dissertations - CAFNR (MU)
    • Biological Engineering electronic theses and dissertations - Engineering (MU)

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