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dc.contributor.advisorJohnson, Gary S.en
dc.contributor.authorAwano, Tomoyukien_US
dc.date.issued2006eng
dc.date.submitted2006 Springen
dc.descriptionTitle from title screen of research.pdf file (viewed on December 22, 2006).en_US
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.description"May 2006"en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2006.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.en_US
dc.description.abstractNeuronal ceroid-lipofuscinosis (NCL), also known as Battens disease, is really a group of inherited neurodegenerative diseases. A common feature of the ceroid lipofuscinoses is the deposition of autofluorescent cytoplasmic storage material in cells in the brain, retina, and many other tissues. The major symptoms are mental retardation, visual failure, lose of motor skills, seizures, and eventually premature death. In the European countries and the USA, the disease affects one in 12,500 to 100,000 people. Usually children appear to be healthy at birth and develop normally until the onset of the disease. Canine NCLs have been reported in a variety of breeds where they are important as veterinary diseases and as potential models for human NCLs. We have discovered that a missense mutation in the CLN8 gene causes NCL in English Setters, a missense mutation in the CTSD gene causes American Bulldog NCL, and frame shift mutation in the CLN2 gene causes Dachshund NCL.en_US
dc.identifier.merlin.b57475234en_US
dc.identifier.otherAwanoT-050506-T5068en_US
dc.identifier.urihttp://hdl.handle.net/10355/4592
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2006 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2006 Theses
dc.subject.lcshDogs -- Diseases -- Genetic aspectsen_US
dc.subject.lcshNeuronal ceroid-lipofuscinosis -- Genetic aspectsen_US
dc.titleThree mutations that cause fifferent [i.e. different] forms of canine neuronal ceroid lipofuscinosisen_US
dc.typeThesisen_US
thesis.degree.disciplineVeterinary biomedical sciencesen_US
thesis.degree.disciplineVeterinary biomedical scienceseng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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