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dc.contributor.advisorJohnson, Gary S.eng
dc.contributor.authorAwano, Tomoyukieng
dc.date.issued2006eng
dc.date.submitted2006 Springeng
dc.descriptionTitle from title screen of research.pdf file (viewed on December 22, 2006).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.description"May 2006"eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description.abstractNeuronal ceroid-lipofuscinosis (NCL), also known as Battens disease, is really a group of inherited neurodegenerative diseases. A common feature of the ceroid lipofuscinoses is the deposition of autofluorescent cytoplasmic storage material in cells in the brain, retina, and many other tissues. The major symptoms are mental retardation, visual failure, lose of motor skills, seizures, and eventually premature death. In the European countries and the USA, the disease affects one in 12,500 to 100,000 people. Usually children appear to be healthy at birth and develop normally until the onset of the disease. Canine NCLs have been reported in a variety of breeds where they are important as veterinary diseases and as potential models for human NCLs. We have discovered that a missense mutation in the CLN8 gene causes NCL in English Setters, a missense mutation in the CTSD gene causes American Bulldog NCL, and frame shift mutation in the CLN2 gene causes Dachshund NCL.eng
dc.identifier.merlin.b57475234eng
dc.identifier.otherAwanoT-050506-T5068eng
dc.identifier.urihttp://hdl.handle.net/10355/4592eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2006 Theseseng
dc.subject.lcshDogs -- Diseases -- Genetic aspectseng
dc.subject.lcshNeuronal ceroid-lipofuscinosis -- Genetic aspectseng
dc.titleThree mutations that cause fifferent [i.e. different] forms of canine neuronal ceroid lipofuscinosiseng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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