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    What therapies alleviate symptoms of polycystic ovary syndrome?

    Moreno, Laura
    Bonnell, Ashley
    Neher, Jon O.
    Safranek, Sarah
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    [PDF] PolycysticOvarySyndrome.pdf (392.9Kb)
    Date
    2015-04
    Contributor
    University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network
    Format
    Article
    Metadata
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    Abstract
    Q: What therapies alleviate symptoms of polycystic ovary syndrome? A: Treatment of polycystic ovary syndrome (PCOS) in women not actively seeking to become pregnant is symptom-specific. Lifestyle modification (LSM) reduces body weight by 3.5 kg (strength of recommendation [SOR]: A, meta-analysis) and metformin reduces it by 3 kg (SOR B, cohort trial). LSM may be better tolerated; adding metformin to LSM doesn’t lead to additional weight loss (SOR: B, randomized controlled trial [RCT]). Spironolactone improves hirsutism scores by an absolute 8% to 22% (SOR: A, multiple RCTs); adding metformin to spironolactone improves Ferriman-Gallwey (FG) hirsutism scores an additional absolute 1.4% (SOR: B, RCT). Oral contraceptive pills (OCPs) are 12 times more likely to result in complete menstrual regularity than metformin (SOR: A, meta-analysis). Combining OCPs with metformin improves hirsutism scores by 8% over using an OCP alone (SOR: A, metaanalysis).
    URI
    https://hdl.handle.net/10355/45949
    Citation
    Journal of Family Practice, 64(4) 2015: 247-249.
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    • Clinical Inquiries, 2015

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