Are cannabinoids safe and effective for treatment of patients with rheumatoid arthritis?
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Are cannabinoids safe and effective for treatment of patients with rheumatoid arthritis? Evidence-Based Answer: Sativex, an oromucosal cannabinoid spray unavailable in the United States, improves pain on movement, pain at rest, and quality of sleep in patients with rheumatoid arthritis; however, the improvements are small and may not be clinically meaningful. Adverse effects including dizziness, lightheadedness, dry mouth, nausea, and falls are significantly more common with Sativex than with placebo (SOR: C, small, low-quality RCT).
Evidence Based Practice 18(5): E2-E3