Vascular smooth muscle calcium waves in isolated arterioles : interactions between intraluminal pressure and intracellular calcium handling
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Arterioles, an important control element in the circulatory system regulate blood flow in part though a phenomenon known as the 'Myogenic Response'. Myogenic response of small vessels is their ability to constrict in response to increase in intraluminal pressure or conversely dilate in response to a reduction in pressure. Calcium (Ca[superscript 2+]) is an important and essential signaling element for myogenic constriction. Apart from steady elevations in smooth muscle intracellular Ca[superscript 2+] in response to agonists or intraluminal pressure, several local and temporal Ca[superscript 2+] events such as sparks, waves, flashes also exist. These temporal Ca[superscript 2+] events are differentially regulated in several vascular beds and are poorly understood. Therefore, the current project aimed to understand the effects of intraluminal pressure on arteriolar vascular smooth muscle Ca+ waves in rat cremaster muscle arterioles. The project aimed to investigate the mechanisms underlying the generation of Ca[superscript 2+] waves and postulate a possible physiological role for the Ca[superscript 2+] waves. Increases in intraluminal pressure increased the Ca[superscript 2+] wave activity, described by the number of cells exhibiting Ca[superscript 2+] waves and their frequency. Ca[superscript 2+] waves occurred due to the activation of the IP3 receptors present on the sarcoplasmic reticulum in the cells. The presence of Ca[superscript 2+] waves in the smooth muscle cells provided a general level of vascular activation, wherein the wave activity is modulated to change the temporal responses of the myogenic behaviour. Elimination of Ca[superscript 2+] waves delayed the myogenic constriction, while increased Ca[superscript 2+] wave activity fastened the myogenic constriction.--From public.pdf
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