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dc.contributor.advisorMcClellan, Andreweng
dc.contributor.authorBenes, Jessica Anneeng
dc.date.issued2006eng
dc.date.submitted2006 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on April 17, 2009)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.A.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological sciences.eng
dc.description.abstractFollowing severe spinal cord injury (SCI), in adult higher vertebrates there is little or no axonal regeneration, and animals remain paralyzed below the lesion. In contrast, lower vertebrates such as the lamprey, following SCI, descending brain neurons, particularly reticulospinal (RS) neurons, regenerate their axons and locomotor function recovers in a few weeks. Following SCI in lamprey, we have shown that axotomized RS neurons change their biophysical properties. Results from the present study suggest that rostral spinal cord transections alter the biophysical properties of axotomized RS neurons to a greater degree than more caudal transections. In addition, injured RS neurons have significantly smaller slow after hyperpolarizations (sAHP) than uninjured RS neurons. The sAHP is due to calcium influx during action potentials. A reduction in the sAHP amplitude in axotomized RS neurons suggests that calcium channels may be down regulated to maintain relatively low intracellular calcium levels and to promote axonal regeneration.eng
dc.identifier.merlinb66786836eng
dc.identifier.oclc318644487eng
dc.identifier.urihttps://hdl.handle.net/10355/4632
dc.identifier.urihttps://doi.org/10.32469/10355/4632eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subjectreticulospinal neurons.eng
dc.subjectreticulospinal neuronseng
dc.subject.lcshNervous system -- Regenerationeng
dc.subject.lcshLampreys -- Larvaeeng
dc.subject.lcshLampreys -- Anatomyeng
dc.subject.lcshVertebrates -- Physiologyeng
dc.titleThe effects of axotomy on the biophysical properties of reticulospinal neurons in larval lampreyeng
dc.typeThesiseng
thesis.degree.disciplineBiological sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.A.eng


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