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dc.contributor.advisorBeerntsen, Brenda T.eng
dc.contributor.authorLaCrue, Alexis Nicholeeng
dc.date.issued2007eng
dc.date.submitted2007 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVita.eng
dc.description"December 2007"eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2007.eng
dc.description.abstractThe Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have been identified and characterized. A novel surface molecule, designated the Sporozoite and Erythrocytic Stage (SES) protein, is preferentially-expressed in salivary gland sporozoites versus oocyst and hemolymph sporozoites of Plasmodium gallinaceum. PgSES exhibits a spiral surface labeling pattern that overlays a known sporozoite surface antigen, the circumsporozoite protein, with only minor co-localization. It consists of 551 amino acids encoding a putative 63.2 kDa protein that has been shown to be expressed not only on particular sporozoite stages, but also during the erythrocytic stages. This novel protein has three conserved regions of unknown function that are present in eight Plasmodium spp. representing human, avian, non-human primate, and rodent malarias. Antibody blocking studies assessing the role of PgSES in sporozoite invasion of mosquito salivary glands show that anti-PgSES antibodies block invasion by 49-87%. The Plasmodium falciparum homolog, PfSES, also appears to have expression during the sporozoite and erythrocytic stages. Additional studies assessing the function of both PgSES and PfSES in the sporozoite and erythrocytic stages are being conducted. Ultimately, if the SES protein is found to be critical to parasite development and/or invasion of host tissues, it could be a target for novel malaria intervention efforts.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.identifier.merlinb66635664eng
dc.identifier.oclc314398457eng
dc.identifier.urihttps://doi.org/10.32469/10355/4648eng
dc.identifier.urihttps://hdl.handle.net/10355/4648
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshPlasmodium -- Molecular aspectseng
dc.subject.lcshProteinseng
dc.subject.lcshVeterinary protozoologyeng
dc.subject.lcshMalaria -- Molecular aspectseng
dc.titleCharacterization of the sporozoite and eythrocytic stages (SES) proteineng
dc.typeThesiseng
thesis.degree.disciplineVeterinary pathobiology area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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