What are the risks of prescribing both a beta-blocker and a calcium channel blocker?
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What are the risks of prescribing both a beta-blocker and a calcium channel blocker? Bottom line: When amlodipine or diltiazem are added to beta-blocker therapy for the treatment of stable inducible angina, 0.9% to 4.5% of patients will discontinue therapy due to intolerable dizziness and about 20% of patients will experience cardiovascular adverse events (AEs) (SOR: B, RCTs). About 0.74% of hospital admissions may be due in part to adverse reactions from such drug combinations (SOR: C, single prospective case series).
Evidence Based Practice 18(7): 14