How well do BNP levels correlate to response of heart failure to therapy?
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How well do BNP levels correlate to response of heart failure to therapy? Evidence-Based Answer: In chronic heart failure (HF) with decreased left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels correspond well with response to therapy. BNP-guided therapies decrease mortality and reduce cardiovascular events, but do not decrease overall hospitalizations (SOR: A, meta-analysis and subsequent RCT).
Evidence Based Practice 18(9): E1-E2