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    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate Studies - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2015 Dissertations (MU)
    • 2015 MU dissertations - Freely available online
    • View Item
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    The Cellular Immune Response to Murine Lyme borreliosis

    Lasky, Carrie Elizabeth
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    [PDF] research.pdf (2.494Mb)
    [PDF] short.pdf (5.371Kb)
    Date
    2015
    Format
    Thesis
    Metadata
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    Abstract
    Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi. There are approximately 300,000 new cases of Lyme Disease reported in the United States each year. Individuals with Lyme disease often suffer from chronic, painful arthritis. Our research uses a mouse model to better understand the immune response to this bacteria. Using an innovative technique, we were able to characterize the cellular immune response with the ankle joints of B. burgdorferi-infected mice. We found unique anti-inflammatory cells within the ankle joints which may provide potential targets for therapeutics in the future. In addition, we identified a detrimental role for T cells during infection in the absence of TLR-2. All studies presented herein provide a foundation on which future studies will be built from in the hopes of providing better treatment for Lyme Disease patients in the future.
    URI
    https://hdl.handle.net/10355/46875
    Degree
    Ph. D.
    Thesis Department
    Microbiology (Medicine) (MU)
    Collections
    • 2015 MU dissertations - Freely available online
    • Molecular Microbiology and Immunology electronic theses and dissertations (MU)

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