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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2015 Dissertations (MU)
    • 2015 MU dissertations - Access restricted to UM
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    Role of copper in defending against bacterial infection

    Ladomersky, Erik
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    [PDF] public.pdf (1.811Kb)
    [PDF] research.pdf (2.486Mb)
    [PDF] short.pdf (11.72Kb)
    Date
    2015
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Copper is an essential nutrient. It plays an important role in development, pigmentation, neurological function, and immune defense. Copper deficiency is known to make host's more susceptible to infection. In this work we show that two copper proteins, ATP7A and ceruloplasmin, are important for host defense against bacterial infection. Studies have shown ATP7A is responsible for increasing copper concentrations inside the phagosome. Our study sheds light on the role of Atp7a and copper in adaptive immunity, and provide a biochemical model for understanding the relationship between copper malnutrition and susceptibility to infection. Iron, another essential nutrient, is linked with copper through the actions of copper-dependent proteins which play a role in maintaining normal iron levels in the blood. One of these proteins is ceruloplasmin, a protein that is also upregulated during infection. Our study sheds light onto why this protein is necessary for host defense against Salmonella infection.
    URI
    https://hdl.handle.net/10355/47147
    Degree
    Ph. D.
    Thesis Department
    Biochemistry (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2015 MU dissertations - Access restricted to UM
    • Biochemistry electronic theses and dissertations (MU)
    • Biochemistry electronic theses and dissertations (MU)

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