Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder
dc.contributor.author | Ferguson, Bradley J. | eng |
dc.contributor.author | Hartnett, Kaitlyn B. | eng |
dc.contributor.author | Marler, Sarah | eng |
dc.contributor.author | Altstein, Lily L. | eng |
dc.contributor.author | Lee, Evon Batey | eng |
dc.contributor.author | Mazurek, Micah O. | eng |
dc.contributor.author | McLaughlin, Aaron | eng |
dc.contributor.author | Macklin, Eric A. | eng |
dc.contributor.author | McDonnell, Erin | eng |
dc.contributor.author | Davis, Daniel | eng |
dc.contributor.author | Belenchia, Anthony M. | eng |
dc.contributor.author | Hagan, Catherine E. | eng |
dc.contributor.author | Peterson, Catherine A. | eng |
dc.contributor.author | Bauman, Margaret L. | eng |
dc.contributor.author | Margolis, Kara Gross | eng |
dc.contributor.author | Veenstra-VanderWeele, Jeremy | eng |
dc.contributor.author | Beversdorf, David Q. | eng |
dc.date.issued | 2015 | eng |
dc.description | Poster | eng |
dc.description.abstract | Autism spectrum disorder (ASD) is characterized by impairments in social communication and abnormal repetitive behavior patterns. Recent studies have shown a strong association between ASD and gastrointestinal (GI) symptomatology. Some individuals with ASD show altered reactivity to stress, as well as altered immune markers, particularly stress responsive cytokines including TNF-alpha and IL-6. To assess potential relationships between GI symptoms and stress response, we examined whether GI symptoms are associated with increases in stress-associated endocrine markers and cytokines in ASD. We also conducted exploratory analyses the examine the relationship between IL-6, TNF-alpha, cortisol, and intelligence, as well as the effects of the presence or absence of co-occurring medical conditions on the relationship between IL-6, TNF-alpha, cortisol, and GI symptoms. Given the aforementioned findings, we expected to find positive relationships between GI symptoms and biomarkers of stress, including cortisol levels, IL-6, and TNF-alpha. | eng |
dc.identifier.uri | https://hdl.handle.net/10355/47333 | eng |
dc.publisher | Published by authors | eng |
dc.subject | Autism spectrum disorder (ASD), cortisol, stress response, GI symptoms, altered immune markers, stress responsive cytokines | eng |
dc.title | Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder | eng |
dc.type | Other | eng |