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dc.contributor.advisorHuxley, Virginiaen
dc.contributor.authorSasaki, Rie, 1977-en_US
dc.date.issued2007eng
dc.date.submitted2007 Summeren
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionVita.en_US
dc.description"August 2007"en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physiology (Medicine).en_US
dc.description.abstractA characteristic of endothelial dysfunction, which is observed in the beginning stages of type 2 diabetes, is the alteration of the microvascular barrier, affecting the microvascular permeability. We measured the venular leakage and clearance of albumin in response to suffusion with high-dose insulin (10-7M) in the autoperfused mesentery in the adult male (AM), adult female (AF), and juvenile male (JM) rats. Insulin suffusion lead to increased venular albumin leakage by 63% in AM rats. Albumin and total protein clearance decreased with insulin treatment. In the JM rats, venular albumin leakage was increased by 103% with insulin suffusion. The total protein clearance in JM was unchanged, while the albumin clearance increased with insulin suffusion. In the AF rats, venular albumin leakage was unchanged with insulin suffusion. Insulin decreased the total protein clearance, but not the albumin clearance. We demonstrated novel data that not only can insulin result in changes in macromolecule exchange in intact, mesenteric microvasculature, but that these changes were dependent on the sex and the sexual maturity of the animal.en_US
dc.identifier.merlin.b61468538en_US
dc.identifier.oclc182537908en_US
dc.identifier.otherSasakiR-073007-D8330en_US
dc.identifier.urihttp://hdl.handle.net/10355/4733
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2007 Freely available dissertations (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2007 Dissertations
dc.subject.lcshCapillaries -- Permeabilityen_US
dc.subject.lcshCapillaries -- Effect of drugs onen_US
dc.subject.lcshAlbumins -- Physiological effecten_US
dc.subject.lcshInsulin -- Physiological effecten_US
dc.subject.lcshMicrocirculation disorders -- Sex factorsen_US
dc.subject.meshCapillary Permeability -- drug effectsen_US
dc.subject.meshInsulin -- pharmacologyen_US
dc.subject.meshAlbumins -- drug effectsen_US
dc.subject.meshMicrocirculation -- drug effectsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshVenules -- drug effectsen_US
dc.titleRoles of sex and insulin on microvascular exchange functionen_US
dc.typeThesisen_US
thesis.degree.disciplinePhysiology (Medicine)en_US
thesis.degree.disciplinePhysiology (Medicine)eng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


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