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dc.contributor.advisorHuxley, Virginiaeng
dc.contributor.authorSasaki, Rie, 1977-eng
dc.date.issued2007eng
dc.date.submitted2007 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionVita.eng
dc.description"August 2007"eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2007.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physiology (Medicine).eng
dc.description.abstractA characteristic of endothelial dysfunction, which is observed in the beginning stages of type 2 diabetes, is the alteration of the microvascular barrier, affecting the microvascular permeability. We measured the venular leakage and clearance of albumin in response to suffusion with high-dose insulin (10-7M) in the autoperfused mesentery in the adult male (AM), adult female (AF), and juvenile male (JM) rats. Insulin suffusion lead to increased venular albumin leakage by 63% in AM rats. Albumin and total protein clearance decreased with insulin treatment. In the JM rats, venular albumin leakage was increased by 103% with insulin suffusion. The total protein clearance in JM was unchanged, while the albumin clearance increased with insulin suffusion. In the AF rats, venular albumin leakage was unchanged with insulin suffusion. Insulin decreased the total protein clearance, but not the albumin clearance. We demonstrated novel data that not only can insulin result in changes in macromolecule exchange in intact, mesenteric microvasculature, but that these changes were dependent on the sex and the sexual maturity of the animal.eng
dc.identifier.merlin.b61468538eng
dc.identifier.oclc182537908eng
dc.identifier.otherSasakiR-073007-D8330eng
dc.identifier.urihttp://hdl.handle.net/10355/4733eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2007 Freely available dissertations (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2007 Dissertationseng
dc.subject.lcshCapillaries -- Permeabilityeng
dc.subject.lcshCapillaries -- Effect of drugs oneng
dc.subject.lcshAlbumins -- Physiological effecteng
dc.subject.lcshInsulin -- Physiological effecteng
dc.subject.lcshMicrocirculation disorders -- Sex factorseng
dc.subject.meshCapillary Permeability -- drug effectseng
dc.subject.meshInsulin -- pharmacologyeng
dc.subject.meshAlbumins -- drug effectseng
dc.subject.meshMicrocirculation -- drug effectseng
dc.subject.meshSex Factorseng
dc.subject.meshVenules -- drug effectseng
dc.titleRoles of sex and insulin on microvascular exchange functioneng
dc.typeThesiseng
thesis.degree.disciplinePhysiology (Medicine) (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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