Roles of sex and insulin on microvascular exchange function

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Roles of sex and insulin on microvascular exchange function

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dc.contributor.advisor Huxley, Virginia en
dc.contributor.author Sasaki, Rie, 1977- en_US
dc.date.accessioned 2010-01-12T18:41:20Z
dc.date.available 2010-01-12T18:41:20Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Summer en
dc.identifier.other SasakiR-073007-D8330 en_US
dc.identifier.uri http://hdl.handle.net/10355/4733
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Vita. en_US
dc.description "August 2007" en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (Ph. D.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Physiology (Medicine). en_US
dc.description.abstract A characteristic of endothelial dysfunction, which is observed in the beginning stages of type 2 diabetes, is the alteration of the microvascular barrier, affecting the microvascular permeability. We measured the venular leakage and clearance of albumin in response to suffusion with high-dose insulin (10-7M) in the autoperfused mesentery in the adult male (AM), adult female (AF), and juvenile male (JM) rats. Insulin suffusion lead to increased venular albumin leakage by 63% in AM rats. Albumin and total protein clearance decreased with insulin treatment. In the JM rats, venular albumin leakage was increased by 103% with insulin suffusion. The total protein clearance in JM was unchanged, while the albumin clearance increased with insulin suffusion. In the AF rats, venular albumin leakage was unchanged with insulin suffusion. Insulin decreased the total protein clearance, but not the albumin clearance. We demonstrated novel data that not only can insulin result in changes in macromolecule exchange in intact, mesenteric microvasculature, but that these changes were dependent on the sex and the sexual maturity of the animal. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2007 Freely available dissertations (MU) en_US
dc.subject.lcsh Capillaries -- Permeability en_US
dc.subject.lcsh Capillaries -- Effect of drugs on en_US
dc.subject.lcsh Albumins -- Physiological effect en_US
dc.subject.lcsh Insulin -- Physiological effect en_US
dc.subject.lcsh Microcirculation disorders -- Sex factors en_US
dc.subject.mesh Capillary Permeability -- drug effects en_US
dc.subject.mesh Insulin -- pharmacology en_US
dc.subject.mesh Albumins -- drug effects en_US
dc.subject.mesh Microcirculation -- drug effects en_US
dc.subject.mesh Sex Factors en_US
dc.subject.mesh Venules -- drug effects en_US
dc.title Roles of sex and insulin on microvascular exchange function en_US
dc.type Thesis en_US
thesis.degree.discipline Physiology (Medicine) en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US
dc.identifier.merlin .b61468538 en_US
dc.identifier.oclc 182537908 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2007 Dissertations


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