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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2007 Dissertations (MU)
    • 2007 MU dissertations - Freely available online
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    The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease

    Miller, Rebecca Louise, 1974-
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    [PDF] research.pdf (1.673Mb)
    Date
    2007
    Format
    Thesis
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    Abstract
    Parkinson's disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. In this study, we examined the source of reactive oxygen species (ROS) and the underlying signaling pathway for paraquat-induced cytotoxicity to BV-2 microglial cells. Paraquat-induced ROS production was attenuate by inhibitors for NADPH oxidase, protein kinase C and extracellular signal-regulated kinases 1/2. Under inflammatory conditions, microglial cells respond to cytokines by induction of inducible nitric oxide synthase which produces nitric oxide (NO). Our results show that paraquat inhibited cytokine-induced NO production but only moderately enhanced ROS production in microglial cells. We wanted to determine the role of NADPH oxidase in neuronal cells. Paraquat induced the upregulation of the p67phox subunit protein and NOX2 mRNA of NADPH oxidase in differentiated SH-SY5Y cells. In conclusion, our data suggest that NADPH oxidase plays a significant role in the toxicity of paraquat.
    URI
    https://doi.org/10.32469/10355/4764
    https://hdl.handle.net/10355/4764
    Degree
    Ph. D.
    Thesis Department
    Medical Pharmacology and Physiology (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Medical Pharmacology and Physiology electronic theses and dissertations (MU)
    • 2007 MU dissertations - Freely available online

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