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dc.contributor.advisorKorthuis, Ronald J.eng
dc.contributor.authorYusof, Mozow, 1976-eng
dc.date.issued2007eng
dc.date.submitted2007 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2007.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- pharmacology.eng
dc.description.abstractIschemia followed by reperfusion (I/R) is now well-recognized as one form of acute inflammation in which leukocytes play a key role. Preconditioning is a phenomenon through which antecedent exposure to a particular stimulus confers protection against a subsequent prolonged ischemic event. The development of a protected phenotype occurs in response to a diverse array of preconditioning stimuli; each of these preconditioning stimuli appears to promote the production of the gaseous monoxide, nitric oxide (NO), as an initial triggering event in the acquisition of tolerance to I/R. Recent work has shown that NO acts as an endogenous regulator of a second gaseous signaling molecule with vasorelaxant properties, hydrogen sulfide (H₂S). Similar to NO, H₂S has the ability to fulfill a physiologic role in regulating cardiovascular function, distinct from its toxicologic effect. This dissertation shows that H₂S inhibits inflammation after I/R injury, through four separate, yet not necessarily distinct, mechanisms. The aims of this dissertation addressed the hypothesis that H₂S elicits a preconditioning stimulus and protects against I/R injury through an eNOS-/p38 MAPK-/K channel-/HO-1 dependent mechanism.eng
dc.identifier.merlin.b66635627eng
dc.identifier.oclc314399271eng
dc.identifier.otherYusofM-030309-D9190eng
dc.identifier.urihttp://hdl.handle.net/10355/4779eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.meshAnti-inflammatory agentseng
dc.subject.meshNitric Oxide -- metabolismeng
dc.subject.meshIschemic Preconditioningeng
dc.subject.meshHydrogen Sulfide -- pharmacologyeng
dc.subject.meshIschemia -- prevention & controleng
dc.titleAntecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestineeng
dc.typeThesiseng
thesis.degree.disciplinePharmacology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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