Recent Submissions

  • Does knuckle popping lead to arthritis? 

    Powers, Tye; Kelsberg, Gary; Safranek, Sarah (2016-10)
    Q: Does knuckle popping lead to arthritis? Evidence-based answer: No, habitual knuckle popping, or cracking (over the course of several decades) isn’t associated with clinical or radiographic evidence of osteoarthritis ...
  • Which SSRIs most effectively treat depression in adolescents? 

    DeLucia, Valory; Kelsberg, Gary; Safranek, Sarah (2016-09)
    Q: Which SSRIs most effectively treat depression in adolescents? Evidence-based answer: We don’t know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared ...
  • Which treatments are safe and effective for chronic sinusitis? 

    Over, Darrell R. (2016-11)
    Q: Which treatments are safe and effective for chronic sinusitis? Evidence-based answer: for adults with chronic rhinosinusitis (crs), intranasal steroid (ins) therapy is more likely than placebo to improve symptoms (50% ...
  • Which patients with metabolic syndrome benefit from metformin? 

    Stover, Liz; Kelsberg, Gary; Safranek, Sarah (2016-11)
    Q Which patients with metabolic syndrome benefit from metformin? Evidence-based answer: patients at highest risk for progression to diabetes benefit from metformin. In patients with metabolic syndrome who are in the ...
  • How do clinical prediction rules compare with joint fluid analysis in diagnosing gout? 

    Westerfield, Katie L; Mounsey, Anne; Nashelsky, Joan (2016-11)
    Q: How do clinical prediction rules compare with joint fluid analysis in diagnosing gout? Evidence-based answer: clinical prediction rules effectively diagnose gout without joint fluid analysis. The American College of ...
  • Which nonhormonal treatments are effective for hot flashes? 

    Kelsberg, Gary; Maragh, Leticia; Safranek, Sarah (2016-05)
    Q Which nonhormonal treatments are effective for hot flashes? Evidence-based answer: Selective serotonin reuptake inhibitors (SSRIs [fluoxetine, sertraline, paroxetine]) and the selective norepinephrine reuptake inhibitor ...
  • Does caffeine intake during pregnancy affect birth weight? 

    Adams, Taralee; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-03)
    Q: Does caffeine intake during pregnancy affect birth weight? Evidence-based answer: No. Reducing caffeinated coffee consumption by 180 mg of caffeine (the equivalent of 2 cups) per day after 16 weeks-gestation doesn't ...
  • Is lower BP worth it in higher-risk patients with diabetes or coronary disease? 

    Kelsberg, Gary; Russell, Telly; Safranek, Sarah (Family Physicians Inquiries Network, 2016-02)
    Q: Is lower BP worth it in higher-risk patients with diabetes or coronary disease? Evidence-based answer: There is no simple answer; the risk/benefit picture is complicated. Controlling blood pressure to a target of 130/80 ...
  • Do corticosteroid injections improve carpal tunnel syndrome symptoms? 

    Lyon, Corey; Syfert, Jonathan; Nashelsky, Joan (Family Physicians Inquiries Network, 2016-02)
    Q: Do corticosteroid injections improve carpal tunnel syndrome symptoms? Evidence-based answer: Yes. injected corticosteroids reduce symptoms of carpal tunnel syndrome (CTS) more effectively than placebo or systemic steroids, ...