Is phenobarbital effective in treating alcohol withdrawal?
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Is phenobarbital effective in treating alcohol withdrawal? Evidence-Based Answer: It may have a role. Adding IV phenobarbital to lorazepam in the emergency department (ED) decreases ICU admissions compared with lorazepam alone, decreases total ED lorazepam dosing, and reduces the need for continuous IV lorazepam. As individual agents, phenobarbital and lorazepam appear to have comparable effectiveness in lowering Clinical Institute Withdrawal Assessment (CIWA) scores in the ED (SOR: B, small RCTs).
Evidence-Based Practice 19, no. 1 (2016): 6-7