Does lowering systolic blood pressure below 120 mmHg yield positive health benefits beyond those seen at 140 mmHg?
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Does lowering systolic blood pressure below 120 mmHg yield positive health benefits beyond those seen at 140 mmHg? Evidence-Based Answer: No. There is no apparent benefit to therapeutically lowering systolic blood pressure (SBP) below 120 mmHg compared with below 140 mmHg (SOR: A, multiple RCTs and systematic reviews) in patients with grade 1 hypertension and no history of cardiovascular (CV) disease. In fact, lowering SBP below 120 mmHg has been found to be associated with increased adverse events in the subpopulation of patients with hypertension and type 2 diabetes (SOR: B, based on a single high-quality study). (Editor's note: However, data from the SPRINT trial, published November 26, 2015 [SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-2016] suggests tighter control may have some benefit in certain groups.)
Evidence-Based Practice 19, no. 01 (2016): 11-12.