Does treatment with nondaily statin dosing reduce cardiovascular risk?
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Does treatment with nondaily statin dosing reduce cardiovascular risk? Evidence-Based Answer: Nondaily statin dosing (weekly or alternate-day dosing) results in greater lowering of low-density lipoprotein cholesterol (LDL-C) and LDL-C goal achievement compared with statin discontinuation and no difference in LDL-C goal achievement compared with daily dosing (SOR: C, RCT and nonrandomized trials of disease-oriented outcomes). Nondaily statins are recommended as an option for patients who have been unable to tolerate several statins with daily dosing (SOR: C, expert opinion). The effect on patient-oriented outcomes is unclear.
Evidence-Based Practice 19, no. 01 (2016): E1-E2.