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dc.contributor.advisorKilway, Kathleen V., 1963-eng
dc.contributor.authorWeiler, Rachel Ann
dc.date.issued2015
dc.date.submitted2015 Falleng
dc.descriptionTitle from PDF of title page, viewed on March21, 2016en
dc.descriptionDissertation advisor: Kathleen V. Kilwayen
dc.descriptionVitaen
dc.descriptionIncludes bibliographical references (pages 214-218)en
dc.descriptionThesis (Ph.D.)--Department of Chemistry and School of Pharmacy and School of Dentistry. University of Missouri--Kansas City, 2015en
dc.description.abstractThere are approximately one million hip and knee replacements each year in the United States alone and over 70% are cemented for stabilization. The number of these replacements is expected to rise to 3.5 million per year by 2030 and result in an estimated several fold increase of the current global market of a billion to multi-billion dollars over the next fifteen years. The current commercially available polymethyl methacrylate (PMMA) based bone cements have been used since the 1960’s with little change to their composition. They provide strength and longevity for total joint replacements, however they are not without their disadvantages. Issues such as polymerization shrinkage, high curing temperatures, and component toxicity have been reported. In order to address these problems, we replaced the methacrylate-based resin with a silorane-based system, which are novel monomers previously used for dental composites. Our goal is to develop a new bone cement that would have handling times between 10 – 20 min, curing temperatures under 45 °C, good mechanical strength, and biocompatibility. An important part of this effort centered on the identification and investigation of silorane initiation systems, which can be tailored for specific uses including internal bone cements. The initial screening process utilized the neat resin system followed by differing formulations including modified and unmodified fillers. The tests were based in part on the ISO standard 5833 used for acrylic resin cements and included exothermicity, degree of cure, biocompatibility, and mechanical strength. From these studies, we identified alternative bone cement formulations, which met or exceeded our desired properties as compared to commercially available bone cement.eng
dc.description.tableofcontentsIntroduction to biomaterials -- Chemical and mixed initiation systems -- Silorane-based bone cement -- Appendix A. Material and methods -- Appendix B. Chemical initiation table of acids and inhibitorsen
dc.format.extentxvii, 225 pagesen
dc.identifier.urihttps://hdl.handle.net/10355/48338
dc.subject.lcshBone cementsen
dc.subject.meshBone Cementsen
dc.subject.otherDissertation -- University of Missouri--Kansas City -- Chemistryen
dc.subject.otherDissertation -- University of Missouri--Kansas City -- Pharmacyen
dc.subject.otherDissertation -- University of Missouri--Kansas City -- Dentistryen
dc.titleThe Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterialeng
dc.typeThesiseng
thesis.degree.disciplineChemistry (UMKC)en
thesis.degree.disciplinePharmaceutical Sciences (UMKC)en
thesis.degree.disciplineOral and Craniofacial Sciences (UMKC)en
thesis.degree.grantorUniversity of Missouri--Kansas Cityen
thesis.degree.levelDoctoralen
thesis.degree.namePh.D.en


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