Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system

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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system

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dc.contributor.advisor Weisman, Gary A. en
dc.contributor.author Kong, Qiongman, 1979- en_US
dc.date.accessioned 2010-01-12T18:43:37Z
dc.date.available 2010-01-12T18:43:37Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Summer en
dc.identifier.other KongQ-030509-D8325 en_US
dc.identifier.uri http://hdl.handle.net/10355/4847
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on March 19, 2009) en_US
dc.description Vita. en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (Ph.D.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Neuroscience. en_US
dc.description.abstract It is well known that ATP acts as a classic neurotransmitter in the central nervous system. It is stored in synaptic vesicles, released upon neuronal excitation, and activates both ion channel receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or ischemic tissue and have been reported to affect inflammatory events in the brain and many other tissues, however, these inflammatory events as well as the subtype(s) of nucleotide receptor(s) influencing these events have not been well defined. This dissertation examines the expression patterns of P2X and P2Y nucleotide receptors in rat primary cultures of cortical neurons (rPCNs), in adult rodent brains, in cerebral ischemia and in collared rabbit carotid arteries. P2Y₂R is up-regulated in response to cytokine stimulation in rPCNs in vitro and after collar transplantation around rabbit carotid arteries in vivo. Moreover, in vivo studies in the collared carotid artery model indicate the involvement of P2Y₂Rs in the development of intimal hyperplasia. Based on these studies, particular emphasis was placed on delineating the role of the P2Y₂ receptor subtype in neuronal inflammation and the P2X₇ receptor subtype in neuronal apoptosis in the central nervous system. In the rat primary cultures of cortical neurons, activation of the P2Y₂R and P2X₇R caused á-secretase-dependent APP processing and caspase8/9/3-dependent apoptosis, respectively. These results suggest the important roles of P2 nucleotide receptors (P2Y₂R and P2X₇R) and their associated signaling pathways in regulating neuronal inflammation and apoptosis in brain disorders and neurodegeneration. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2007 Freely available dissertations (MU) en_US
dc.subject.lcsh Adenosine triphosphatase en_US
dc.subject.lcsh Neurotransmitters en_US
dc.subject.lcsh Central nervous system en_US
dc.subject.lcsh Polymerase chain reaction en_US
dc.title Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system en_US
dc.type Thesis en_US
thesis.degree.discipline Neuroscience en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph.D. en_US
thesis.degree.level Doctoral en_US
dc.identifier.merlin .b66660920 en_US
dc.identifier.oclc 316337914 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2007 Dissertations


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