What is the most effective treatment for a patient with symptoms of chronic mucocutaneous candidiasis (CMC)?
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What is the most effective treatment for a patient with symptoms of chronic mucocutaneous candidiasis (CMC)? Evidence-Based Answer: For patients with CMC, 6-month therapy with a systemic azole may be effective (SOR: B, single RCT). Daily oral fluconazole has been recommended as first-line treatment (SOR: C, expert opinion). Should resistance develop, treatment should be individualized based on Candida albicans culture susceptibility and clinical response; options include posaconazole, echinocandins, and amphotericin B, with the need for maintenance antifungal therapy likely (SOR: C, case reports and expert opinion).
Evidence-Based Practice 19, no. 03 (2016): 14.