11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissue

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11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissue

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/4909

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dc.contributor.advisor Keisler, Duane H. en
dc.contributor.author Farias, Fabiana Helena Geraldo en_US
dc.date.accessioned 2010-01-12T19:05:57Z
dc.date.available 2010-01-12T19:05:57Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Summer en
dc.identifier.other FariasF-072707-T7671 en_US
dc.identifier.uri http://hdl.handle.net/10355/4909
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on January 3, 2008) en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri--Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Animal sciences. en_US
dc.description.abstract Enzymatic 11 [beta] HSD1 amplification of glucocorticoid concentrations in adipose tissue has been associated with obesity, diabetes, hypertension, dyslipidemia, and cardiovascular disease in humans and mice. Unfortunately, very little is known about 11 [beta] HSD1 in other species. Therefore, three species were studied to determine if 11 [beta] HSD1 activity existed in adipose tissue in a species dependent manner and if so, did the amount of enzymatic activity differ with respect to specific adipose depots within that species. Feline (carnivore): fat samples were collected from 6 cats, each sampled from 5 different adipose depots. immunohistochemically, 11 [beta] HSD1 was found in each of the adipose depots. Level of 11 [beta] HSD1 activity differed with depot and cat tested (P [lesser than] 0.05). Morphometric analyses revealed that adipocyte diameters differed (P [lesser than] .05) with adipose depot and cat, however, adipocyte volume did not correlate with level of 11 [beta] HSD1 activity. Equine (herbivore): fat samples were collected from the abdominal and subcutaneous adipose depots of 23 horses. immunohistochemically, 11 [beta] HSD1 was present in equine adipose, but level of activity did not differ with depot, nor body condition score of the horse. Porcine (omnivore): fat samples were collected from abdominal and subcutaneous adipose depots from 8 Ossabaw pigs. Immunohistochemical analysis revealed the presence of 11 [beta] HSD1 in porcine, but the level of activity did not differ between tissue depots. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.subject.lcsh Enzyme activation en_US
dc.subject.lcsh Dehydrogenases en_US
dc.subject.lcsh Adipose tissue en_US
dc.subject.lcsh Glucocorticoids en_US
dc.subject.lcsh Immunohistochemistry en_US
dc.title 11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissue en_US
dc.type Thesis en_US
thesis.degree.discipline Animal sciences en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b61730646 en_US
dc.identifier.oclc 187141515 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.relation.ispartofcollection 2007 Freely available theses (MU)


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