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dc.contributor.advisorKeisler, Duane H.eng
dc.contributor.authorFarias, Fabiana Helena Geraldoeng
dc.date.issued2007eng
dc.date.submitted2007 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on January 3, 2008)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri--Columbia 2007.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.eng
dc.description.abstractEnzymatic 11 [beta] HSD1 amplification of glucocorticoid concentrations in adipose tissue has been associated with obesity, diabetes, hypertension, dyslipidemia, and cardiovascular disease in humans and mice. Unfortunately, very little is known about 11 [beta] HSD1 in other species. Therefore, three species were studied to determine if 11 [beta] HSD1 activity existed in adipose tissue in a species dependent manner and if so, did the amount of enzymatic activity differ with respect to specific adipose depots within that species. Feline (carnivore): fat samples were collected from 6 cats, each sampled from 5 different adipose depots. immunohistochemically, 11 [beta] HSD1 was found in each of the adipose depots. Level of 11 [beta] HSD1 activity differed with depot and cat tested (P [lesser than] 0.05). Morphometric analyses revealed that adipocyte diameters differed (P [lesser than] .05) with adipose depot and cat, however, adipocyte volume did not correlate with level of 11 [beta] HSD1 activity. Equine (herbivore): fat samples were collected from the abdominal and subcutaneous adipose depots of 23 horses. immunohistochemically, 11 [beta] HSD1 was present in equine adipose, but level of activity did not differ with depot, nor body condition score of the horse. Porcine (omnivore): fat samples were collected from abdominal and subcutaneous adipose depots from 8 Ossabaw pigs. Immunohistochemical analysis revealed the presence of 11 [beta] HSD1 in porcine, but the level of activity did not differ between tissue depots.eng
dc.identifier.merlin.b61730646eng
dc.identifier.oclc187141515eng
dc.identifier.otherFariasF-072707-T7671eng
dc.identifier.urihttp://hdl.handle.net/10355/4909eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshEnzyme activationeng
dc.subject.lcshDehydrogenaseseng
dc.subject.lcshAdipose tissueeng
dc.subject.lcshGlucocorticoidseng
dc.subject.lcshImmunohistochemistryeng
dc.title11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissueeng
dc.typeThesiseng
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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