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dc.contributor.advisorKeisler, Duane H.en
dc.contributor.authorFarias, Fabiana Helena Geraldoen_US
dc.date.issued2007eng
dc.date.submitted2007 Summeren
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from title screen of research.pdf file (viewed on January 3, 2008)en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri--Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.en_US
dc.description.abstractEnzymatic 11 [beta] HSD1 amplification of glucocorticoid concentrations in adipose tissue has been associated with obesity, diabetes, hypertension, dyslipidemia, and cardiovascular disease in humans and mice. Unfortunately, very little is known about 11 [beta] HSD1 in other species. Therefore, three species were studied to determine if 11 [beta] HSD1 activity existed in adipose tissue in a species dependent manner and if so, did the amount of enzymatic activity differ with respect to specific adipose depots within that species. Feline (carnivore): fat samples were collected from 6 cats, each sampled from 5 different adipose depots. immunohistochemically, 11 [beta] HSD1 was found in each of the adipose depots. Level of 11 [beta] HSD1 activity differed with depot and cat tested (P [lesser than] 0.05). Morphometric analyses revealed that adipocyte diameters differed (P [lesser than] .05) with adipose depot and cat, however, adipocyte volume did not correlate with level of 11 [beta] HSD1 activity. Equine (herbivore): fat samples were collected from the abdominal and subcutaneous adipose depots of 23 horses. immunohistochemically, 11 [beta] HSD1 was present in equine adipose, but level of activity did not differ with depot, nor body condition score of the horse. Porcine (omnivore): fat samples were collected from abdominal and subcutaneous adipose depots from 8 Ossabaw pigs. Immunohistochemical analysis revealed the presence of 11 [beta] HSD1 in porcine, but the level of activity did not differ between tissue depots.en_US
dc.identifier.merlin.b61730646en_US
dc.identifier.oclc187141515en_US
dc.identifier.otherFariasF-072707-T7671en_US
dc.identifier.urihttp://hdl.handle.net/10355/4909
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartofcollection2007 Freely available theses (MU)
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.subject.lcshEnzyme activationen_US
dc.subject.lcshDehydrogenasesen_US
dc.subject.lcshAdipose tissueen_US
dc.subject.lcshGlucocorticoidsen_US
dc.subject.lcshImmunohistochemistryen_US
dc.title11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissueen_US
dc.typeThesisen_US
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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