Should you use progesterone in a postmenopausal patient with a uterus on chronic vaginal estrogen?
Metadata[+] Show full item record
Should you use progesterone in a postmenopausal patient with a uterus on chronic vaginal estrogen? Evidence-Based Answer: No. Endometrial hyperplasia has been seen with vaginal estrogens of various types, but this condition is rare and the rate is not different from that associated with placebo (SOR: A, systematic review of RCTs and subsequent RCT). Women at high risk for endometrial carcinoma may benefit from some surveillance if vaginal estrogen is used for more than 1 year, as incidence data for hyperplasia are lacking beyond this time frame (SOR: C, evidence based guideline).
Evidence-Based Practice 19, no. 5 (2016): 11-12