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dc.contributor.advisorRobertson, John David, 1960-eng
dc.contributor.authorGuthrie, James McKameyeng
dc.date.issued2007eng
dc.date.submitted2007 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on October 25, 2007)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstractNumerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail Mn levels. Interest in the status of Mn, a necessary trace nutrient which may also have toxic effects upon overexposure, stems from two recent developments: first, a greater awareness of the role of Mn-based enzymes in human health, and second, a renewed controversy over the use of a Mn-containing gasoline additive in Canada. In order to evaluate the hypothesis, toenail specimens from One Source multivitamin users and matched controls were selected. Using the NAA technique, Se was measured using established methods, and then Mn was measured via a new procedure. The Se results confirmed the accurate classification of the cohort. However, the nail did not demonstrate significant, positive response to Mn supplementation. Several explanations for this lack of response may be offered, including the confounding effect of other, unknown dietary variables; Mn blood level regulation by homeostatic mechanisms; and the masking of endogenous Mn in the toenail by persistent Seleniumexogenous material.eng
dc.identifier.merlinb60917854eng
dc.identifier.oclc176912802eng
dc.identifier.urihttps://hdl.handle.net/10355/4929
dc.identifier.urihttps://doi.org/10.32469/10355/4929eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theseseng
dc.subject.lcshBiological monitoringeng
dc.subject.lcshToenailseng
dc.subject.lcshSelenium in human nutritioneng
dc.subject.lcshManganese in human nutritioneng
dc.titleEvaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohorteng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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