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dc.contributor.advisorGiuliano, Elizabeth A.en
dc.contributor.authorOta, Jurien_US
dc.date.issued2007eng
dc.date.submitted2007 Springen
dc.description"May 2007"en_US
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionVita.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery.en_US
dc.description.abstractThe objectives of the present studies were to evaluate the use of local photodynamic therapy (PDT) on tumor growth inhibition in a murine model of squamous cell carcinoma (SCC). SCC was induced in nude mice by injection of a human SCC cell line. In study 1 (dose effect), two treatment groups received intra-tumoral injection of verteporfin at a dose of 0.01, 0.1 or 1.0 mg/cm3 dissolved in DMSO. Controls received only DMSO or no injectate. In study 2 (solvent effect), two treatment groups received verteporfin (0.1mg/cm3) dissolved in 5% dextrose solution (D5W) or DMSO. Controls received solvent only. All groups received identical light illumination (100 J/cm2). Relative change in tumor volume (RCTV) at day 15 and 30 was compared between groups using Wilcoxon-Rank Sum test (significance: p<0.05). In study1, RCTV in 0.01 mg/cm3 group was not different to control groups. RCTV in 0.1 mg/cm3 group was reduced compared with both control groups and the 0.01 mg/cm3 group. In study 2, treatment with vertporfin in DMSO resulted in a lower RCTV than controls. No significant difference in RCTV was found between verteporfin in D5W vs. DMSO. Local PDT using verteporfin at a dose of 0.1 mg/cm3 and a light dose of 100 J/cm3 effectively inhibited the growth of SCC in this model at day 15 and 30. Choice of solvent (DMSO vs. D5W) did not affect the results. Local PDT may be an effective adjunctive therapy for the treatment of equine SCC.en_US
dc.identifier.merlin.b59291990en_US
dc.identifier.oclc163612960en_US
dc.identifier.otherOtaJ-040607-T6347en_US
dc.identifier.urihttp://hdl.handle.net/10355/4934
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2007 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.subject.lcshHorses -- Diseasesen_US
dc.subject.lcshSquamous cell carcinoma -- Photochemotherapyen_US
dc.subject.lcshSquamous cell carcinoma -- Animal modelsen_US
dc.subject.lcshEye -- Tumorsen_US
dc.titleLocal photodynamic therapy for equine squamous cell carcinoma in a murine modelen_US
dc.typeThesisen_US
thesis.degree.disciplineVeterinary medicine and surgeryen_US
thesis.degree.disciplineVeterinary medicine and surgeryeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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