Local photodynamic therapy for equine squamous cell carcinoma in a murine model

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Local photodynamic therapy for equine squamous cell carcinoma in a murine model

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/4934

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dc.contributor.advisor Giuliano, Elizabeth A. en
dc.contributor.author Ota, Juri en_US
dc.date.accessioned 2010-01-12T19:06:48Z
dc.date.available 2010-01-12T19:06:48Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Spring en
dc.identifier.other OtaJ-040607-T6347 en_US
dc.identifier.uri http://hdl.handle.net/10355/4934
dc.description "May 2007" en_US
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Vita. en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery. en_US
dc.description.abstract The objectives of the present studies were to evaluate the use of local photodynamic therapy (PDT) on tumor growth inhibition in a murine model of squamous cell carcinoma (SCC). SCC was induced in nude mice by injection of a human SCC cell line. In study 1 (dose effect), two treatment groups received intra-tumoral injection of verteporfin at a dose of 0.01, 0.1 or 1.0 mg/cm3 dissolved in DMSO. Controls received only DMSO or no injectate. In study 2 (solvent effect), two treatment groups received verteporfin (0.1mg/cm3) dissolved in 5% dextrose solution (D5W) or DMSO. Controls received solvent only. All groups received identical light illumination (100 J/cm2). Relative change in tumor volume (RCTV) at day 15 and 30 was compared between groups using Wilcoxon-Rank Sum test (significance: p<0.05). In study1, RCTV in 0.01 mg/cm3 group was not different to control groups. RCTV in 0.1 mg/cm3 group was reduced compared with both control groups and the 0.01 mg/cm3 group. In study 2, treatment with vertporfin in DMSO resulted in a lower RCTV than controls. No significant difference in RCTV was found between verteporfin in D5W vs. DMSO. Local PDT using verteporfin at a dose of 0.1 mg/cm3 and a light dose of 100 J/cm3 effectively inhibited the growth of SCC in this model at day 15 and 30. Choice of solvent (DMSO vs. D5W) did not affect the results. Local PDT may be an effective adjunctive therapy for the treatment of equine SCC. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2007 Freely available theses (MU) en_US
dc.subject.lcsh Horses -- Diseases en_US
dc.subject.lcsh Squamous cell carcinoma -- Photochemotherapy en_US
dc.subject.lcsh Squamous cell carcinoma -- Animal models en_US
dc.subject.lcsh Eye -- Tumors en_US
dc.title Local photodynamic therapy for equine squamous cell carcinoma in a murine model en_US
dc.type Thesis en_US
thesis.degree.discipline Veterinary medicine and surgery en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b59291990 en_US
dc.identifier.oclc 163612960 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses


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