Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2007 Theses (MU)
    • 2007 MU theses - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Theses (MU)
    • 2007 Theses (MU)
    • 2007 MU theses - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Computational modeling of sensory circuitry in the nucleus tractus solitarii from arterial baroreceptor and somatosensory inputs

    Gummadavalli, Pavan Kumar
    View/Open
    [PDF] public.pdf (2.110Kb)
    [PDF] short.pdf (30.76Kb)
    [PDF] research.pdf (5.755Mb)
    Date
    2007
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    Baroreflex function regulates the arterial blood pressure in our body. The baroreflex is considered to be an integrated negative feedback system. NTS (Nucleus tractus solitarius) is one of key subsystems in this baroreflex loop. In the past, NTS has been considered primarily as a relay cell but later it was determined that it plays a major role in the baroreflex function. It has been found that the NTS is a site for the integration of sensory information from different variables in the body. This lead to further studies on the properties of the NTS neurons and how it affects the baroreflex function. The present study is an effort to characterize the NTS at both the single cell and network levels using computational models which are subsequently used to investigate hypotheses regarding NTS functions. With known biological data about NTS cells, the models are used to investigate properties such as pulse synchronicity at intermediate stages in the NTS. The inputoutput relationship at the first synapse of the NTS is studied first using a single cell network and a transfer function model. The underlying causes for a lack of pulse synchronicity at the second order NTS neuron is then investigated using a population level network model. Finally, a somatic afferent is added to the population model through another GABA population to study the possible effect of exercise on this baroreflex function.
    URI
    https://hdl.handle.net/10355/4941
    https://doi.org/10.32469/10355/4941
    Degree
    M.S.
    Thesis Department
    Electrical and computer engineering (MU)
    Collections
    • 2007 MU theses - Freely available online
    • Electrical Engineering and Computer Science electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems