Does adjuvant treatment with coenzyme Q10 improve statin tolerance?
No, use of coenzyme Q10 supplementation does not affect rates of statin-induced myopathy (SOR: B, metaanalysis of RCTs). Coenzyme Q10 is not associated with any change in the number of patients remaining on statin therapy (SOR: B, RCT). In the event of statininduced myopathy, current guidelines recommend discontinuation of original statin therapy, establishment of a causal relationship, and initiation of a different statin with gradual dose uptitration as tolerated (SOR: B, evidence-based guideline).
Evidence-Based Practice 19, no. 4 (2016): 5