Is warfarin safe and effective for prevention of noncardioembolic ischemic stroke?
No, do not use warfarin to prevent thrombotic stroke. Warfarin is no better than aspirin for secondary prevention after a noncardioembolic ischemic stroke, and it carries an increased risk of bleeding and death (SOR: A, systematic reviews of RCTs).
Evidence-Based Practice 19, no. 4 (2016): 5-6