Is bilateral lower extremity edema a marker for undiagnosed sleep apnea in adults?
Perhaps. Among patients who already have a diagnosis of obstructive sleep apnea (OSA), the presence of edema may indicate greater OSA severity, even after adjusting for confounders such as body mass index (BMI). The finding of edema appears to be independent of measureable pulmonary hypertension (SOR: C, small cohort and cross-sectional trials).
Evidence-Based Practice 19, no. 4 (2016): 9-10