Is paroxetine a safe and effective treatment for vasomotor symptoms?
From a baseline of 6 to 12 hot flashes per day, paroxetine decreases the frequency of vasomotor symptoms by approximately 1 to 2 hot flashes per day over placebo and decreases the severity slightly. Paroxetine has a low incidence of serious adverse events (SOR: A, RCTs with homogeneous results). Paroxetine decreases nighttime awakenings attributed to vasomotor symptoms more than placebo (SOR: B, single RCT).
Evidence-Based Practice 19, no. 6 (2016): 10-12