Are tricyclic antidepressants effective at improving symptoms of ADHD in children and adolescents?
Are tricyclic antidepressants effective at improving symptoms of ADHD in children and adolescents? Evidence-based answer: The tricyclic antidepressants (TCAs) desipramine, clomipramine, and nortriptyline reduce attention deficit hyperactivity disorder (ADHD) symptoms in the short term in children and adolescents (SOR: B, metaanalyses of lower quality RCTS). TCAs can be used in children with ADHD not responding to methylphenidate, dexamphetamine, and atomoxetine (SOR: B, guideline based on RCTs).
Evidence-Based Practice 19, no. 6 (2016): E1-E2